Ibakala leGMP iAtosiban acetate yokutofa
| Igama leGeneric: | Atosiban Acetate |
| Inombolo yeCas: | 914453-95-5 |
| Ifomula yemolekyuli: | I-C45H71N11O14S2 |
| Ubunzima bemolekyuli: | 1054.25 g/mol |
| Ulandelelwano: | Mpr-D-Tyr(OEt)-Ile-Thr-Asn-Cys-Pro-Orn-Gly-NH2 |
| Imbonakalo: | Umgubo omhlophe okhululekileyo |
| Isicelo: | I-Atosiban yi-peptide yokwenziwa esebenza njenge-oxytocin receptor antagonist.Isetyenziswa ngokuyintloko kwi-obstetrics kunye ne-gynecology ukucinezela ukunyanzeliswa kwangaphambili kwesibeleko, oku kunokukhokelela ekusebenzeni kwangaphambili.Ngokuthintela isenzo se-oxytocin, ihomoni enoxanduva lokuvuselela ukuqhawuka kwesibeleko, i-Atosiban inceda ukulibazisa ukuqala kokubeleka kunye nokwandisa ixesha lokukhulelwa. Eli liyeza lilawulwa nge-intravenously kwaye lidla ngokusetyenziswa ekukhulelweni okusemngciphekweni omkhulu apho ukuzalwa kwangaphambi kwexesha kuyinkxalabo.Kuyinzuzo ngakumbi kwiimeko apho ubudala bokukhulelwa buphakathi kwe-24 kunye ne-33 yeeveki.I-Atosiban yaziwa ngokunciphisa ngokufanelekileyo ukuphindaphindeka kunye nokuqina koxinzelelo, ibonelela ngefestile yamathuba okwenziwa kolunye ungenelelo, njengokulawula i-corticosteroids ukukhulisa ukukhula kwemiphunga yomntwana. I-Atosiban ixhatshazwe kakuhle, kunye nemiphumo embalwa.Nangona kunjalo, kunokubangela ukusabela okungephi, okunje ngentloko ebuhlungu, isicaphucaphu, kunye nokugungxulwa.Kwiimeko ezinqabileyo, kunokukhokelela kwiingxaki ezinzima ngakumbi, ezifana nokungaphenduli okanye iziphumo ze-cardiovascular effects.Ke ngoko, kubalulekile kubasebenzi bezempilo ukuba babeke iliso elibukhali kwizigulana ezifumana i-Atosiban. Ngokubanzi, i-Atosiban idlala indima ebalulekileyo kulawulo lwemisebenzi yangaphambi kwexesha, inceda ekuphuculeni iziphumo zosana ngokuvumela ixesha elide lokumitha.Sisixhobo esibalulekileyo kwinkalo yokubelekisa, encedisa ekuthinteleni ukuzalwa kwangaphambi kwexesha kunye nokunika iintsana ithuba elingcono kwisiqalo esinempilo ebomini. |
| Umqulu: | ibhegi yefoyile ye-aluminiyam okanye i-TIN ye-aluminium okanye ngokweemfuno zomthengi |
| 1 | Umthengisi oqeqeshiweyo we-peptide APIs evela eTshayina. |
| 2 | Imigca yemveliso eyi-16 enomthamo omkhulu owaneleyo wemveliso kunye nexabiso elikhuphisanayo |
| 3 | I-DMF ifumaneka ngamaxwebhu athembekileyo. |
A: Ewe, singapakisha njengemfuno yakho.
A: I-LC sight kunye ne-TT kwithuba lokuhlawula kwangaphambili elikhethwayo.
IMPENDULO: Ewe, nceda unikezele ngeenkcukacha zakho zomgangatho, siza kujonga kwi-R&D yethu kwaye sizame ukungqamanisa ubunjani bakho.
