Igama leGeneric: | Cagrilintide |
Inombolo yeCas: | 1415456-99-3 |
Ifomula yeemolekyuli: | C194H312N54O59S2 |
Ubunzima bemolekyuli: | 4109 g/mol |
Imbonakalo: | Umgubo omhlophe |
Isicelo: | I-Cagrilintide liyeza elisetyenziselwa ukunyanga isifo seswekile se-2. Yi-peptide yokwenziwa esebenza njenge-agonist kwi-glucagon-like peptide-1 (GLP-1) receptor. I-GLP-1 yihomoni eveliswa emathunjini enceda ukulawula amanqanaba eswekile yegazi. I-Caglilin peptides isebenza ngokuvuselela i-GLP-1 receptor, ekhokelela ekwandeni kwe-insulin secretion, ukuncipha kwe-glucagon secretion, kunye nokukhupha isisu esicothayo. Oku ekugqibeleni kunceda ukulawula amanqanaba eswekile yegazi kubantu abanesifo sikashukela sohlobo lwe-2. Ukongeza kwimiphumo yayo kwi-insulin kunye ne-glucagon secretion, i-caglilintide ineminye imiphumo emihle kunyango lwe-2 yeswekile. Kufunyenwe ukukhuthaza ukuvakalelwa kokuzala, okubangela ukunciphisa ukutya kunye nokulahlekelwa kwesisindo kwezinye izigulane. Oku kubalulekile kuba ukulahlekelwa kwesisindo kuhambelana nokulawulwa kwe-glycemic ephuculweyo kunye nokunciphisa umngcipheko weengxaki zenhliziyo kubantu abanesifo sikashukela sohlobo lwe-2. Ukongezelela, i-canagrelin tide ibonakaliswe ukuba ineenzuzo zenhliziyo. Kufunyenwe ukuphucula umsebenzi wentliziyo kunye nokunciphisa ukuvuvukala kwi-cardiovascular system, ingxaki eqhelekileyo kubantu abanesifo sikashukela. Oku kwenza kube lukhetho oluxabisekileyo kwizigulane ezineswekile kunye nesifo senhliziyo. I-Canagrelin idla ngokutofwa ngaphantsi kwesikhumba kanye okanye kabini yonke imihla. Kubalulekile ukuba izigulane zifumane imfundo efanelekileyo kunye nesikhokelo malunga nendlela yokuzisebenzisa ngokwazo amayeza ukuqinisekisa ukusetyenziswa okusebenzayo nokukhuselekileyo. Njengalo naliphi na iyeza, i-caglilintide ineziphumo ebezingalindelekanga. Ezona ziphumo bezingalindelekanga ziquka isicaphucaphu, ukugabha kunye norhudo. Ezi ziphumo bezingalindelekanga zihlala ziphucuka ngokuhamba kwexesha njengoko umzimba ulungelelanisa amayeza. I-Canagrelin inokunyusa umngcipheko we-hypoglycemia, ngakumbi xa isetyenziswe kunye nezinye ii-antidiabetic agents. Ukuhlolwa rhoqo amanqanaba eswekile yegazi kuyimfuneko ukuthintela kunye nokulawula i-hypoglycemia. Ngokubanzi, i-caglilin tide yongezwa okubalulekileyo kwiinketho zonyango lwezigulane ezinesifo seswekile se-2. Inceda ukulawula amanqanaba eswekile yegazi, ikhuthaza ukunciphisa umzimba, kwaye ineenzuzo zentliziyo. Nangona kunjalo, kubalulekile ukuba izigulana zisebenze ngokusondeleyo kunye nomboneleli wabo wezempilo ukugqiba ukuba i-canagrelintide lukhetho olufanelekileyo kubo kunye nokuqinisekisa ukuba ichiza lisetyenziswa ngokukhuselekileyo nangempumelelo. |
Umqulu: | ibhegi yefoyile ye-aluminiyam okanye i-TIN ye-aluminium okanye ngokweemfuno zomthengi |
1 | Umthengisi oqeqeshiweyo we-peptide APIs evela eTshayina. |
2 | Imigca yemveliso eyi-16 enomthamo omkhulu owaneleyo wemveliso kunye nexabiso elikhuphisanayo |
3 | Imveliso iveliswa kwi-US FDA kunye ne-EDQM indawo evunyiweyo. |
A: Ewe, singapakisha njengemfuno yakho.
A: I-LC sight kunye ne-TT kwithuba lokuhlawula kwangaphambili elikhethwayo.
IMPENDULO: Ewe, nceda unikezele ngeenkcukacha zomgangatho wakho, siza kujonga kwi-R&D yethu kwaye sizame ukungqamanisa ubunjani bakho.