Ibakala leGMP iDegarelix acetate API enefayile yeDMF
| Igama leGeneric: | Degarelix acetate |
| Inombolo yeCas: | 214766-78-6 |
| Ifomula yeemolekyuli: | I-C82H103ClN18O16 |
| Ubunzima bemolekyuli: | 1632.28 g/mol |
| Ulandelelwano: | Ac-D-2-Nal-D-4-Cpa-D-3-Pal-Ser-4-amino-Phe(L-hydroorotyl)-4-ureido- D-Phe-Leu-Lys(isopropyl)-Pro- Ityuwa ye-acetate ye-D-Ala-NH2 |
| Imbonakalo: | Umgubo omhlophe |
| Isicelo: | I-Degarelix acetate lichiza elisetyenziselwa ukunyanga umhlaza wedlala lesinyi. Yeyodidi lwamachiza abizwa ngokuba yi-gonadotropin-releasing hormone (GnRH) antagonists. Ngokungafaniyo ne-GnRH agonists, eqala ukuvuselela imveliso ye testosterone kwaye emva koko iphantsi kwe testosterone, i-degarelix acetate ivimba ngokuthe ngqo isenzo se-GnRH, ngaloo ndlela inciphisa amanqanaba e-testosterone emzimbeni. Ngokwehlisa amanqanaba e-testosterone, i-degarelix acetate inceda ukucothisa ukukhula kweeseli zomhlaza wedlala lesidoda. Itofwa phantsi kwesikhumba kanye ngenyanga. I-Degarelix acetate ibonakaliswe ukuba iyasebenza ekwehliseni ngokukhawuleza amanqanaba e-testosterone kunye nokuwagcina ngaphakathi koluhlu olufunekayo kunyango lomhlaza wesibeleko. I-Degarelix acetate lukhetho olubalulekileyo lonyango lwamadoda anomhlaza wesibeleko esiphezulu angakwaziyo okanye anganqweneli ukwenza utyando okanye athathe amayeza omlomo athoba amanqanaba e-testosterone. Ngokuqhelekileyo inyamezeleke kakuhle, kwaye iziphumo ebezingalindelekanga eziqhelekileyo ziquka ukusabela kwendawo yokutofa, ukubila, ukukhanya okushushu, kunye nokuncipha kwe-libido. Lilonke, i-degarelix acetate lukhetho olusebenzayo nolungqiniweyo lonyango lomhlaza wedlala lesinyi, inceda ukulawula isifo kunye nokuphucula umgangatho wobomi besigulana. |
| Umqulu: | ibhegi yefoyile ye-aluminiyam okanye i-TIN ye-aluminium okanye ngokweemfuno zomthengi |
| 1 | Umthengisi oqeqeshiweyo we-peptide APIs evela eTshayina. |
| 2 | Imigca yemveliso eyi-16 enomthamo omkhulu owaneleyo wemveliso kunye nexabiso elikhuphisanayo |
| 3 | I-GMP kunye ne-DMF zifumaneka ngowona maxwebhu athembekileyo. |
A: Ewe, singapakisha njengemfuno yakho.
A: I-LC sight kunye ne-TT kwithuba lokuhlawula kwangaphambili elikhethwayo.
IMPENDULO: Ewe, nceda unikezele ngeenkcukacha zomgangatho wakho, siza kujonga kwi-R&D yethu kwaye sizame ukungqamanisa ubunjani bakho.
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