Kwinqanaba lakutshanje le-3, i-Tirzepatide ibonise iziphumo ezikhuthazayo kunyango lwe-2 yeswekile. Ichiza lifunyenwe ukunciphisa kakhulu amanqanaba eswekile yegazi kunye nokukhuthaza ukulahleka kwesisindo kwizigulane ezinesifo.
I-Tirzepatide yinaliti esebenza kanye ngeveki esebenza ngokujolisa kwi-glucagon-like peptide-1 (GLP-1) kunye ne-glucose exhomekeke kwi-insulinotropic polypeptide (GIP) receptors. Ezi zamkeli zidlala indima ephambili ekulawuleni amanqanaba eswekile yegazi kunye nokukhuthaza ukuveliswa kwe-insulin.
Ulingo, oluqhutywa ngu-Eli Lilly kunye neNkampani, babhalisa abantu abangaphezu kwe-1,800 abanesifo sikashukela sohlobo lwe-2 abangazange bathathe i-insulin okanye bathathe umthamo ozinzileyo we-insulin. Abathathi-nxaxheba babelwa ngokungenamkhethe ukuba bafumane inaliti yeveki yeTirzepatide okanye i-placebo.
Ekupheleni kovavanyo lweeveki ezingama-40, abaphandi bafumanisa ukuba izigulane ezifumene i-Tirzepatide zinezinga eliphantsi kakhulu leswekile yegazi kunezo zafumana i-placebo. Ngokomyinge, abathathi-nxaxheba baphathwa nge-Tirzepatide bafumana i-2.5 yepesenti yokunciphisa i-hemoglobin A1c (HbA1c) amanqanaba, xa kuthelekiswa nokunciphisa ipesenti ze-1.1 kwiqela le-placebo.
Ukongeza, abaguli abafumana iTirzepatide nabo bafumana ukwehla kobunzima obukhulu. Ngokomyinge, balahlekelwe yi-11.3 yepesenti yobunzima bomzimba wabo, xa kuthelekiswa ne-1.8 yepesenti kwiqela le-placebo.
Iziphumo zolingo zibaluleke kakhulu xa kujongwa ukuxhaphaka kokunyuka kohlobo lwesi-2 seswekile kwihlabathi jikelele. Ngokutsho koMbutho wezeMpilo weHlabathi, inani labantu abadala abaphila nesifo seswekile liphindwe kane ukususela ngo-1980, kunye nabantu abadala abaqikelelwa kwi-422 yezigidi abachaphazelekayo kwi-2014.
"Ukulawula uhlobo lwe-2 yesifo sikashukela kunokuba ngumngeni kubantu abaninzi, kwaye iindlela ezintsha zonyango zihlala zamkelekile," kusho uDkt Juan Frias, umphandi okhokelayo kwisifundo. "Iziphumo zolu pho nonongo zibonisa ukuba i-Tirzepatide inokunika ukhetho olutsha oluthembisayo kwizigulane ezine-type 2 yeswekile enzima ukulawula amanqanaba eswekile yegazi."
Nangona uphando olongezelelweyo lufuneka ukuhlola ukhuseleko lwexesha elide kunye nokusebenza kwe-Tirzepatide, iziphumo ezikhuthazayo zechiza kolu lingo lwesigaba sesi-3 luphawu olulungileyo kubantu abanesifo seswekile sohlobo lwesi-2. Ukuba ivunyiwe ngamaziko alawulayo, iTirzepatide inokubonelela ngonyango olutsha olusebenzayo lokulawula isifo kunye nokuphucula umgangatho wobomi bezigulane.
Ixesha lokuposa: Jun-03-2023