Uphononongo olutsha lufumanisa ukuba i-semaglutide yeziyobisi inokunceda abantu abanesifo sikashukela sohlobo lwe-2 balahlekelwe isisindo kwaye bayigcine ixesha elide.
I-Semaglutide yi-injection ye-injection kanye ngeveki eye yavunywa yi-FDA ukunyanga uhlobo lwe-2 yeswekile.Ichiza lisebenza ngokukhuthaza ukukhululwa kwe-insulin ekuphenduleni ukutya, okunceda ukulawula amanqanaba eswekile yegazi.Ukongeza, i-semaglutide iphinda icinezele ukutya ngokusebenza kwiziko le-satiety yengqondo.
Uphononongo, olukhokelwa ngabaphandi kwiYunivesithi yaseCopenhagen, baqesha abantu be-1,961 abanesifo sikashukela sohlobo lwe-2 kunye ne-index mass body (BMI) ye-30 okanye ngaphezulu.Abathathi-nxaxheba babelwa ngokungenamkhethe ukuba bafumane ii-injection zeveki ze-semaglutide okanye i-placebo.Bonke abathathi-nxaxheba nabo bafumana iingcebiso zokuziphatha kwaye bakhuthazwa ukuba balandele ukutya okuphantsi kweekhalori kunye nokwandisa umsebenzi womzimba.
Emva kweeveki ze-68, abaphandi bafumanisa ukuba izigulane eziphathwe nge-semaglutide zilahlekelwe umyinge we-14.9 ekhulwini lobunzima bomzimba wabo, xa kuthelekiswa neepesenti ze-2.4 kwiqela le-placebo.Ukongezelela, ngaphezu kweepesenti ze-80 zezigulane eziphathwe nge-semaglutide zilahlekelwe ubuncinane ubuncinane be-5 ekhulwini lobunzima bomzimba wabo, xa kuthelekiswa neepesenti ze-34 zezigulane eziphathwe nge-placebo.Ukulahlekelwa kwesisindo esiphunyeziweyo nge-semaglutide kwagcinwa ukuya kuthi ga kwi-2 iminyaka.
Uphononongo luphinde lwafumanisa ukuba izigulane eziphathwe nge-semaglutide zafumana ukuphuculwa okuphawulekayo kulawulo lweswekile yegazi, uxinzelelo lwegazi kunye namanqanaba e-cholesterol, zonke ezo ziyimingcipheko yesifo senhliziyo.
Iziphumo zolu pho nonongo zibonisa ukuba i-semaglutide ingaba yindlela yonyango esebenzayo kubantu abanesifo sikashukela sohlobo lwe-2 abazama ukunciphisa umzimba.Ishedyuli yokudosa iyeza kanye ngeveki yenza ukuba ibe lukhetho olufanelekileyo kwizigulane ezinobunzima bokubambelela kwirejimeni yedosi yemihla ngemihla.
Izibonelelo zokulahlekelwa kwesisindo se-semaglutide nazo zinokuba nefuthe elibanzi kunyango lokukhuluphala, umngcipheko omkhulu wohlobo lwe-2 yeswekile, isifo senhliziyo kunye nezinye izifo ezingapheliyo.Ukutyeba ngokugqithiseleyo kuchaphazela ngaphezu kwesinye kwisithathu sabantu abadala eUnited States, kwaye unyango olusebenzayo luyafuneka ukulungisa le ngxaki ikhulayo yempilo yoluntu.
Ngokubanzi, iziphumo zophando zibonisa ukuba i-semaglutide inokuba yongezelelo oluxabisekileyo kwiinketho zonyango ezikhoyo kwizigulane ezine-2 yeswekile kunye nokukhuluphala.Nangona kunjalo, njengalo naliphi na iyeza, kubalulekile ukuba izigulana zixoxe ngobungozi obunokubakho kunye neenzuzo kunye nomboneleli wabo wezempilo kwaye balandele ngononophelo idosi emiselweyo kunye nemiyalelo yokubeka iliso.
Ixesha lokuposa: Jun-03-2019